PiMobendan (hydrochloride)

中文名	Pimobendan (hydrochloride)
英文名	Pimobendan (hydrochloride)
别名	盐酸匹莫苯丹匹莫苯丹盐酸盐化合物 T23159
英文别名	PiMobendan (hydrochloride) Pimobendan (hydrochloride) 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone monohydrochloride
CAS	77469-98-8
化学式	C19H19ClN4O2
分子量	370.83276
熔点	311°(dec)
溶解度	10毫米DMSO
存储条件	-20℃
体外研究	Pimobendan hydrochloride (UD-CG115 hydrochloride) exhibits selective inhibition of PDE III isolated from guinea pig cardiac muscle with IC 50 of 0.32 uM compared to the inhibition of PDE I and PDE II (IC 50 >30 μM). In human atrial cells, 100 μM Pimobendan (UD-CG115) significantly increases the L-type calcium current (ICa(L)) (evoked by depolarization to +10 mV from a holding potential of -40 mV) by 250.4% with the half-maximal stimulation (EC 50 ) of 1.13 μM. In rabbit atrial cells, Pimobendan (UD-CG115) increases ICa(L) at +10 mV by 67.4.%, which is significantly lower than that obtained in human atrial cells.
体内研究	Pimobendan (UD-CG115) shows a beneficial effect on survival in the murine model of EMC virus-induced myocarditis. Administration of Pimobendan (UD-CG115) significantly increases the final survival rate from 33.6% (control) to 53.3% (0.1 mg/kg) or 66.7% (1 mg/kg). Pimobendan (UD-CG115) (1 mg/kg) also significantly reduces myocardial cellular infiltration, the level of intracardiac tumor necrosis factor (TNF)-α and interleukin (IL)-1β compared with the control group, which shows no effect on myocardial necrosis, heart weight and body weight. Pimobendan (UD-CG115) suppresses expression of the intracardiac iNOS gene , causing reduction of intracardiac NO production.

MedChemExpress

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CAS: 77469-98-8
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上海麦克林生化科技股份有限公司

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产品名: Pimobendan hydrochloride 去供应商网站查看询盘
CAS: 77469-98-8
产地: 上海
规格: P877425
价格: 10mg-1524,5mg-810
库存: 15天内发货
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上海源叶生物科技有限公司

产品名: Pimobendan (hydrochloride) 去供应商网站查看询盘
CAS: 77469-98-8
产地: 上海
规格: 98%
价格: 10mg 3360
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